Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects: The atherosclerosis risk in communities (ARIC) study

Authors

Salim S. Virani, Michael E. DeBakey Veterans Affairs Medical Center Health Services Research and Development Center of Excellence, United StatesFollow
Ariel Brautbar, Baylor College of Medicine, and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, United States
Brian C. Davis, University of Texas Health Science Center at Houston, United States
Vijay Nambi, Baylor College of Medicine, and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, United States
Ron C. Hoogeveen, Baylor College of Medicine, and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, United States
A Richey Sharrett, Johns Hopkins University Bloomberg School of Public Health, United States
Josef Coresh, Johns Hopkins University Bloomberg School of Public Health, United States
Thomas H. Mosley, University of Mississippi Medical Center, United States
Joel D. Morrisett, Baylor College of Medicine, and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, United States
Diane J. Catellier, University of North Carolina at Chapel Hill, United States

Document Type

Article

Department

Cardiology

Abstract

Background: On the basis of studies with limited statistical power, lipoprotein(a) [Lp(a)] is not considered a risk factor for cardiovascular disease (CVD) in blacks. We evaluated associations between Lp(a) and incident CVD events in blacks and whites in the Atherosclerosis Risk in Communities (ARIC) study.
Methods and results: Plasma Lp(a) was measured in blacks (n=3467) and whites (n=9851). Hazards ratios (HRs) for incident CVD events (coronary heart disease and ischemic strokes) were calculated. Lp(a) levels were higher with wider interindividual variation in blacks (median [interquartile range], 12.8 [7.1-21.7] mg/dL) than whites (4.3 [1.7-9.5] mg/dL; P10 to ≤20 mg/dL, >20 to ≤30 mg/dL, and >30 mg/dL.
Conclusions: Lp(a) levels were positively associated with CVD events. Associations were at least as strong, with a larger range of Lp(a) concentrations, in blacks compared with whites.

Comments

This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

Circulation

Recommended Citation

Virani, S. S., Brautbar, A., Davis, B. C., Nambi, V., Hoogeveen, R. C., Sharrett, A. R., Coresh, J., Mosley, T. H., Morrisett, J. D., Catellier, D. J. (2012). Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects: The atherosclerosis risk in communities (ARIC) study. Circulation, 125(2), 241-249.
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