Title

In vitro antifungal activity of 9, 10-dihydrophenanthrene-2- carboxylic acid isolated from a marine bacterium: Pseudomonas putida

Document Type

Article

Department

Paediatrics and Child Health

Abstract

An antifungal compound 9, 10-dihydrophenanthrene - 2 - carboxylic acid was isolated from a marine derivedbacterium Pseudomonas putida isolated from surface water samples of Karachi fish harbor coast line. The structure wasexplored using extensive 1D- and 2D-NMR spectroscopic techniques.
The compound was found to be active againstfungal strains obtained from clinical samples whereas strong activity was noted against Candida albicans with a MICvalue of 20µg/ml, as the purified compound showed promising anticandidal activity a multidisciplinary approach isneeded to explore further this compound as potential pharmacological lead compound against Candida spp and will addin the global hunt for clinically functional antifungal agents.

Publication

Pakistan journal of pharmaceutical sciences

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