Secretor and Salivary ABO Blood Group Antigen Status Predict Rotavirus Vaccine Take in Infants
Paediatrics and Child Health
Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.
The Journal of Infectious Diseases
Kazi, A. M.,
Cortese, M. M.,
Morrow, A. L.,
Fleming, J. A.,
McNeal, M. M.,
Steele, A. D.,
Parashar, U. D.,
Zaidi, A. K.
(2017). Secretor and Salivary ABO Blood Group Antigen Status Predict Rotavirus Vaccine Take in Infants. The Journal of Infectious Diseases, 215(5), 786-789.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_women_childhealth_paediatr/607