Paediatrics and Child Health
In a prospective study we compared two different dosage regimens of IV chloramphenicol succinate (100 mg/kg/day and 75 mg/kg/day) in children with culture proven typhoid. Trough and peak blood samples, obtained at 48 hrs, were analysed for free chloramphenicol by high pressure liquid chromatography (HPLC). Although the mean trough (8.8 +/- 7.7 versus 5.4 +/- 2.6 mcg/ml) and peak (19.9 +/- 12.2 versus 15.4 +/- 6.1 mcg/ml) chloramphenicol concentrations were comparable in both groups, a significantly wider range was found in the group receiving 100 mg/kg/day. Potentially toxic levels (greater than 30 mcg/ml) developed in two patients with liver dysfunction. Chloramphenicol in a dosage of 75 mg/kg/day is adequate and safe for the treatment of paediatric typhoid.
Journal of Pakistan Medical Association
Bhutta, Z. A.,
Naqvi, S. H.,
(1991). Chloramphenicol therapy of typhoid fever. Journal of Pakistan Medical Association, 41(2), 26-30.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_women_childhealth_paediatr/430