Evolution of systemic therapy in medulloblastoma including irradiation-sparing approaches

Authors

Naureen Mushtaq, Aga Khan UniversityFollow
Rahat Ul Ain, University of Child Health Sciences, Pakistan
Syed Ahmer Hamid, Indus Hospital & Health Network, Pakistan
Eric Bouffet, St. Jude Children's Research Hospital, United Staes

Document Type

Article

Department

Radiation Oncology

Abstract

The management of medulloblastoma in children has dramatically changed over the past four decades, with the development of chemotherapy protocols aiming at improving survival and reducing long-term toxicities of high-dose craniospinal radiotherapy. While the staging and treatment of medulloblastoma were until recently based on the modified Chang's system, recent advances in the molecular biology of medulloblastoma have revolutionized approaches in the management of this increasingly complex disease. The evolution of systemic therapies is described in this review.

Comments

Pagination is not provided by the author/publisher.

Publication (Name of Journal)

Diagnostics

DOI

https://doi.org/10.3390/diagnostics13243680

Recommended Citation

Mushtaq, N., Ain, R., Hamid, S. A., Bouffet, E. (2023). Evolution of systemic therapy in medulloblastoma including irradiation-sparing approaches. Diagnostics, 13(24).
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_radiat_oncol/102