Pattern of bone marrow involvement in non hodgkin's lymphoma classified according to WHO classification: report of a developing country Pakistan

Authors

Sadia Sultan, Liaquat National Hospital and Medical College.Follow
Naseer Baloch, Liaquat National Medical College.
Zeeshan Ansar Ahmed, Aga Khan UniversityFollow
Syed Mohammad Irfan, Liaquat National Hospital and Medical College.
Saira Parveen, Liaquat National Hospital and Medical College.

Document Type

Article

Department

Pathology and Laboratory Medicine

Abstract

BACKGROUND: Limited information is available from developing countries in patients of non-Hodgkin's lymphoma (NHL). Hence, we reviewed the demographical profile along with bone marrow infiltration pattern in patients with NHL presented at Liaquat National Hospital and Medical College. MATERIALS AND METHODS: In this descriptive study, adult patients with NHL were enrolled from January 2011 to December 2015. RESULTS: One hundred and Eighty-four histopathologically confirmed cases of NHL were identified. There were 139 males and 45 females, with a male-to-female ratio of 3:1. The mean age was 48.5 ± 16.0 years with the median age of 50 years. B-symptoms were present in 80.4% of patients. Lymph node enlargement was present in 71.1% of the cases. One hundred and sixty-eight patients had B-cell lymphoma (91.3%) and 16 patients had T-cell lymphoma (8.6%). Overall 158 (85.8%) patients had aggressive lymphoma. The frequency of bone marrow infiltration in our NHL patients was found to be 31.5%. Pattern of infiltrate was diffuse (14.6%) predominantly followed by interstitial (6.5%) and paratrabecular (5.4%) types of infiltration. The least common was nodular infiltrate accounted in 9 (4.8%) patients. CONCLUSIONS: B-cell lymphoma is more frequent than T-cell lymphoma. Younger age, aggressive lymphoma, and predominance of B-symptoms are more frequently seen. Diffuse bone marrow infiltration is more common in our set up probably because of a relatively late presentation in our patients.

Publication (Name of Journal)

Journal of Laboratory Physicians

Recommended Citation

Sultan, S., Baloch, N., Ahmed, Z. A., Irfan, S. M., & Parveen, S. (2018). Pattern of bone marrow involvement in non hodgkin's lymphoma classified according to WHO classification: report of a developing country Pakistan. Journal of Laboratory Physicians, 10(1), 17-20.