Title

Outcome of adult acute lymphoblastic leukemia: a single center experience

Document Type

Article

Department

Haematology/Oncology; Pathology and Microbiology

Abstract

Acute lymphoblastic leukemia (ALL) in adults is a rare malignancy. It represents 1-2% of all cancers1, however it accounts for 20% of adult leukemias. Adult ALL is a heterogeneous disease significantly different from childhood ALL. There are marked differences both in terms of biological factors and clinical outcomes.2 The complete remission rates with induction therapy program in adult ALL ranges from 60-90% but the 5-year disease free survival is only 25-35%. This is in contrast to childhood ALL in which the complete remission rates and overall survival are about 80%.In adults poor outcome is associated with older age, high white cell count and Philadelphia chromosome positivity.3-7 There are a number of studies about the outcomes of adults diagnosed to have ALL in the literature. However, such information is sparse from our part of the world. This study was designed to describe the survival outcomes of adult patients with ALL seen in a Pakistani population.

Publication

Journal of Pakistan Medical Association

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