Document Type
Article
Department
Pathology and Microbiology; Haematology/Oncology
Abstract
Fludarabine is a purine nucleoside analogue, which inhibits DNA synthesis by inhibiting DNA polymerase and ribonucleoside reductase.1 It affects both dividing and non- dividing cells.2 Fludarabine possesses proven efficacy in the treatment of a variety of indolent B cell lymphoproliferative disorders including chronic lymphocytic leukemia3, low-grade non-Hodgkin's lymphoma4 and Waldenstrom macroglobulinemia.5 It is also a part of conditioning regimes in non-myeloablative bone marrow transplantation.6 The common side effects include myelosuppression, immunosuppression, and neurologic toxicity.7 The rare side effects are immune mediated hemolytic anemia8 and thrombocytopenia.9 Here we describe a case of a middle-aged lady who was diagnosed as B cell chronic lymphocytic leukemia and developed immune mediated thrombocytopenia following oral Fludarabine.
Publication (Name of Journal)
Journal of Pakistan Medical Association
Recommended Citation
Usman, M.,
Adil, S.,
Sajid, R.,
Khurshid, M.
(2003). Fludarabine induced immune thrombocytopenia in a patient with CD5 positive B cell chronic lymphocytic leukemia. Journal of Pakistan Medical Association, 53(10), 1-2.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/563