Rapid sarcomatous transformation of an ameloblastic fibroma of the mandible: Case report and literature review
Document Type
Article
Department
Pathology and Microbiology
Abstract
Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumour regarded as the malignant counterpart of ameloblastic fibroma. It is characterized by a benign epithelial component within a malignant fibrous stroma. AFS is a locally aggressive neoplasm with extremely low potential for metastasis. We report an extremely rare, rapidly progressive, and fatal case originating in the posterior mandible of a 20-year old female Patient. Initially histopathologically diagnosed as a benign lesion, it rapidly recurred with apparent transformation into a high-grade sarcoma over a period of 6 months. Subsequent intracranial and pulmonary metastases were noted, and the Patient died within 15 months of initial consultation. This case emphasizes the need for a high element of suspicion about clinically ambiguous lesions. We recommend more extensive or radical, primary excisions in lesions that have a known potential for recurrence or malignancy.
Publication (Name of Journal)
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
Recommended Citation
Kousar, A.,
Hosein, M.,
Ahmad, Z.,
Minhas, K.
(2009). Rapid sarcomatous transformation of an ameloblastic fibroma of the mandible: Case report and literature review. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 108(3), E80-E85.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/177