Phyllodes tumor of breast in pediatric and adolescent population: A detailed clinicopathological study of 22 cases

Document Type

Article

Department

Pathology and Laboratory Medicine

Abstract

Introduction: Phyllodes tumor (PT) are rarely seen in young population. Some authors believe that PT behave less aggressively in young patients and the need for aggressive management is questioned.
Objective: We aimed to describe the clinicopathological features of PT in pediatric and adolescent population.
Methodology: We reviewed the reports and microscopy glass slides of PT from 22 pediatric and adolescent patients (≤20 years old), diagnosed between 2010 and 2024.
Results: Eighteen cases were malignant PT (MPT), 3 benign PT, and 1 borderline PT. Median patient's age was 17 years (range: 14-20). Median tumor size was 11.25 cm (range: 1.3-22). Tumor margins were either positive or < 1 mm away in 10/17 (58.9%) tumor excisions. Follow up information was available for 12 MPT patients with median follow up duration of 26.5 months. Recurrence was observed in 2/10 (20%) primary MPT cases at 2- and 3-months interval. Distant metastasis was observed in 4/12 (33.3%) cases at median interval of 12 months. One of the metastatic cases and another patient without definite treatment, died of disease.
Conclusion: We observed higher frequency of MPT patients, larger tumor size, and higher rate of mastectomy. MPT behave aggressively as evidenced by recurrence, metastasis, and tumor-related death.

Publication (Name of Journal)

Pediatric and Developmental Pathology

DOI

10.1177/10935266251369273

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