Primary drug resistance to antituberculous drugs in Punjab Pakistan

Authors

Arshad Javaid, Lady Reading Hospital Peshawar
Rumina Hasan, Aga Khan UniversityFollow
Afia Zafar, Aga Khan University

Document Type

Article

Department

Pathology and Laboratory Medicine

Abstract

Objective: To assess the prevalence of Primary drug resistance in PunjabIntroduction/ Methods: Tuberculosis is a serious public health problem. Pakistan ranks 6th in terms of TB burden with a WHO estimated incidence rate of 181 per 100,000 persons. This study was a cross-sectional prevalence study, evaluating the prevalence of drug resistance among new TB patients, using a non-probability convenience sampling methodology. The sample size was calculated according to the population & WHO’s estimated incidence of smear positive tuberculosis in the province/country. Sputum samples were obtained from 430 newly diagnosed patients of pulmonary tuberculosis from various centres in Lahore, Rawalpindi & Multan.Results: Sensitivities were performed by proportion method which showed the following resistance values in 387 eligible patients. 42 (10.8 %) samples showed primary resistance to one or more drugs. 28 (7.2%) of the isolates tested were resistant to a single drug, 8 (2.0%) were resistant to 2 drugs, 2 (0.5%) to 3 drugs, 3 (0.75%) to 4 drugs while one (0.25%) to all 5 first line agents.*Department of Pulmonology, PGMI, Lady Reading Hospital Peshawar, ** King Edward Medical UniversityLahore, ***Nishtar Medical College Multan, +Allama Iqbal Medical Lahore, ++Gulab Devi Hospital Lahore,++National TB Control Program, ++++Department of Microbiology Agha Khan University Hospital Karachi.2Resistance to Streptomycin (10μg/ml) was seen in 19 (5.9%), Isoniazid (1μg/ml) in 27(7.0%), Rifampicin (5μg/ml) in 5 (1.2%), Ethambutol (10μg/ml) in 9 (2.3%) andPyrazinamide in 7 (1.8%) samples. Primary Multidrug resistance was in 4 (1.0 %)patients (Isoniazid 1μg/ml, rifampicin 5 μg/ml with or without other drugs).Conclusion: This study from province wide samples suggests that prevalence of MDRamongst untreated patients in Punjab is 1.0%, which is a cause of concern and shouldbe addressed through effective TB control programs with DOTS strategy.

AKU Student

no

Publication (Name of Journal)

Pakistan Journal of Chest Medicine

Recommended Citation

Javaid, A., Hasan, R., Zafar, A. (2011). Primary drug resistance to antituberculous drugs in Punjab Pakistan. Pakistan Journal of Chest Medicine, 17(1).
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/1661