Tuberculosis and diabetes mellitus: Relating immune impact of co-morbidity with challenges in disease management in high burden countries

Document Type

Article

Department

Pathology and Laboratory Medicine; Medicine

Abstract

Mycobacterium tuberculosis (MTB) is the causative agent of TB. TB incidence is high in many low resource settings where limited health systems make it difficult for screening of co-morbid conditions. Susceptibility to TB is increased with coincident diabetes mellitus (DM) or prediabetes. DM leads to chronic, subclinical inflammation in the host leading to compromised protective immunity against MTB, impacting TB treatment. This review focuses on the immunological impact of DM and prediabetes on TB infections, highlighting the importance of having effective diagnostic, treatment and management programs for early identification of hyperglycemia in TB patients to improve treatment outcomes. Further, it describes challenges in monitoring of TB and DM comorbidity in a high-burden setting

Comments

Issue and pagination are not provided by the author/publisher.

Publication (Name of Journal)

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

DOI

10.1016/j.jctube.2022.100343

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