Mycobacterium tuberculosis genotypes in patients developing pulmonary tuberculosis related acute respiratory distress syndrome
Document Type
Article
Department
Pathology and Laboratory Medicine
Abstract
Background: Acute Respiratory Distress Syndrome is an uncommon but frequently fatal presentation of pulmonary TB. We attempted to identify whether a specific M. tuberculosis genotype occurs more commonly in patients who develop ARDS.
Methods: An observational study carried out at the Aga Khan University Hospital, Karachi, Pakistan enrolled all ARDS patients with tuberculosis. MTB isolates were spoligotyped for strain identification.
Results: 725 patients were admitted with pulmonary tuberculosis during the study period. Only 2.5% (18 patients) developed ARDS. Inpatient mortality rate was 58% (7 patients). Genotypes of M. tuberculosis isolates were predominantly CAS I (58.3%) and Unique strains (25%). Beijing and CAS subfamilies were less common; with each genotype identified in 8.3% patients respectively. All except one of the isolated strains were sensitive to usual first line anti-tubercular drugs.
Publication (Name of Journal)
Sri Lanka Journal of Critical Care
DOI
10.4038/sljcc.v2i1.2370
Recommended Citation
Salahuddin, N.,
Tanveer, M.,
Rao, N. A.,
Akram, S.,
Hasan, Z.,
Hasan, R.
(2011). Mycobacterium tuberculosis genotypes in patients developing pulmonary tuberculosis related acute respiratory distress syndrome. Sri Lanka Journal of Critical Care, 2(1), 20-24.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/1531
