Low-grade small round cell tumor of the cauda equina with EWSR1-WT1 fusion and indolent clinical course
Pathology and Laboratory Medicine
We report a case of a longstanding, large tumor involving spinal nerve roots of the cauda equina. The tumor showed small round cells arranged in nests and cords and immunophenotypic features of a glomus tumor, along with infrequent mitoses and a low Ki-67 labeling index, but exhibited some rosette-like structures, with focal CD99 and Neu-N expression. Subsequent molecular analysis showed the presence of an EWSR1-WT1 gene fusion by fluorescence in situ hybridization, which was confirmed by reverse- transcriptase polymerase chain reaction. To our knowledge, this is the first case reported with EWSR1-WT1 fusion in a small round blue cell tumor with smooth muscle differentiation and an indolent course.
Publication ( Name of Journal)
Ud Din, N.,
Horvai, A. E.,
Navarro, A. L.,
(2015). Low-grade small round cell tumor of the cauda equina with EWSR1-WT1 fusion and indolent clinical course. Human Pathology, 46(1), 153-158.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/1073