Low-grade small round cell tumor of the cauda equina with EWSR1-WT1 fusion and indolent clinical course
Document Type
Report
Department
Pathology and Laboratory Medicine
Abstract
We report a case of a longstanding, large tumor involving spinal nerve roots of the cauda equina. The tumor showed small round cells arranged in nests and cords and immunophenotypic features of a glomus tumor, along with infrequent mitoses and a low Ki-67 labeling index, but exhibited some rosette-like structures, with focal CD99 and Neu-N expression. Subsequent molecular analysis showed the presence of an EWSR1-WT1 gene fusion by fluorescence in situ hybridization, which was confirmed by reverse- transcriptase polymerase chain reaction. To our knowledge, this is the first case reported with EWSR1-WT1 fusion in a small round blue cell tumor with smooth muscle differentiation and an indolent course.
Publication (Name of Journal)
Human Pathology
Recommended Citation
Ud Din, N.,
Pekmezci, M.,
Javed, G.,
Horvai, A. E.,
Ahmad, Z.,
Faheem, M.,
Navarro, A. L.,
Lopez-Terrada, D.,
Perry, A.
(2015). Low-grade small round cell tumor of the cauda equina with EWSR1-WT1 fusion and indolent clinical course. Human Pathology, 46(1), 153-158.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/1073