Tackling a deadly global phenomenon: Sepsis induced coagulopathy: A narrative review
Document Type
Article
Department
Medical College Pakistan; Community Health Sciences; Internal Medicine
Abstract
Sepsis is a potentially fatal illness marked by organ failure and the two main causes of which are shock and disseminated intravascular coagulation. Multi-organ dysfunction in sepsis is mediated by the inflammatory cytokine storm, while sepsis induced coagulopathy is mediated and accelerated by activation of pro-coagulative mechanisms. Regardless of the severity of sepsis, disseminated intravascular coagulation is a potent predictor of mortality in septic patients. Additionally, oxidative stress in sepsis causes renal ischaemia and eventually acute kidney injury. The first and foremost goal is to initiate resuscitation immediately, with treatment mainly focussing on maintaining a balance of coagulants and anticoagulants. A simpler and more universal diagnostic criteria is likely to improve studies on the spectrum associated with sepsis.
Publication (Name of Journal)
Journal of the Pakistan Medical Association
DOI
10.47391/JPMA.10194
Recommended Citation
Arshad, A.,
Ahmed, W.,
Rehman, N.,
Naseem, Z.,
Ghos, Z.
(2024). Tackling a deadly global phenomenon: Sepsis induced coagulopathy: A narrative review. Journal of the Pakistan Medical Association, 74(5), 959-966.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_med_intern_med/259