Document Type
Case Report
Department
Haematology/Oncology; Pathology and Microbiology; Pathology and Laboratory Medicine
Abstract
BK virus is well known to be associated with allograft failure in renal transplant recipients due to polyomavirus-associated nephropathy (PVAN). BK viruses are increasingly recognized an important cause of hemorrhagic cystitis during hematopoietic stem cell transplantation (HSCT). Here we describe two patients with acute lymphoblastic leukemia who received a haplo identical match related donor hematopoietic stem cell transplant after myeloablative conditioning and post-transplant cyclophosphamide. They developed cytology proven BK Virus cystitis. Both were treated with Leflunomide. Treatment was effective in alleviating the symptoms temporarily but eventually the symptoms progressed and resulted in mortality of both patients.
Publication (Name of Journal)
Advances in Cytology & Pathology
Recommended Citation
Shakeel, D.,
Ali, N.,
Shaikh, M.,
Adil, S.
(2017). BK polyomavirus virus hemorrhagic cystitis following allogeneic bone marrow transplant with haploidentical related donor: Case reports from two patients. Advances in Cytology & Pathology, 2(4), 128-131.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_med_haematol_oncol/87
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