Outcome of donor and recipient sex match versus mismatch in stem cell transplant procedure

Authors

Natasha Bahadur Ali, Aga Khan UniversityFollow
Hayat Ullah, Bolan Medical Complex Hospital, Quetta, Pakistan
Mohammad Usman Shaikh, Aga Khan UniversityFollow
Salman Adil, Aga Khan UniversityFollow

Document Type

Article

Department

Haematology/Oncology

Abstract

Aim: We determined the frequency of graft-versus-host disease (GvHD) and overall survival (OS) in sex matched vs mismatched transplant.
Methods: Medical records were analyzed of patients undergoing transplant from 2004 to 2016. Variables included age, sex of patient and donor, indication, conditioning regimen, stem cell source, frequency of GvHD and OS.
Results: We performed n = 162 allogeneic stem cell transplants. The most common conditioning regimen was busulfan/cyclophosphamide (n = 64). There was no difference in the frequency of GvHD in both groups. The transplant related mortality was higher (8.7%) in sex-mismatched transplants. The OS in both groups was similar.
Conclusion: Our study showed higher transplant-related mortality in sex-mismatched transplant. There was no difference in GvHD and OS in both groups.

Comments

Pagination are not provided by the author/publisher

Publication (Name of Journal)

International Journal of Hematologic Oncology

Recommended Citation

Ali, N., Ullah, H., Shaikh, M., Adil, S. (2019). Outcome of donor and recipient sex match versus mismatch in stem cell transplant procedure. International Journal of Hematologic Oncology, 8(4), IJH21.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_med_haematol_oncol/59