The effect of cytotoxic and anti-inflammatory drugs on the phagocytosis of neutrophil leucocytes
Document Type
Article
Department
Haematology/Oncology
Abstract
The phagocytosis of heat-killed Candida albicans by neutrophil leucocytes was inhibited in vitro by phenylbutazone and acctylsalicylic acid and by the cytotoxic drugs vincristine, vinblastine, cytosinc arabinoside, daunorubicin and busulphan, but not by mustinc hydrochloride or procarbazine. In vivo studies in man have shown a significant reduction in phagocytosis after phenylbutazone ingestion, but not following an oral dose of aspirin. Possible explanatory mechanisms of drug action on neutrophil phagocytosis are discussed.
Publication (Name of Journal)
British Journal of Haematology
Recommended Citation
Whittaker, J.,
Hughes, H.,
Khurshid, M.
(1975). The effect of cytotoxic and anti-inflammatory drugs on the phagocytosis of neutrophil leucocytes. British Journal of Haematology, 29(2), 273-278.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_med_haematol_oncol/31