Document Type
Article
Department
Gastroenterology
Abstract
Hepatitis C is a major risk factor for the development of hepatocellular carcinoma (HCC), arising typically on a background of liver cirrhosis. Treatment of hepatitis C has been revolutionized by the addition of oral direct-acting antivirals (DAAs) with sustained virological response (SVR) rates above 90%. There is a recent concern under debate about the increased risk of early HCC recurrence in patients with chronic hepatitis C who were treated with direct-acting antivirals. Nonetheless, these reports mostly focused on patients who were cirrhotic and were already treated for HCC. We report 4 cases of treatment naive, chronic hepatitis C patients who were treated with DAAs and rapidly developed infiltrative HCC despite achieving SVR. Moreover, in our scenario, one of the patients appeared clinically non-cirrhotic until he developed HCC.
Publication (Name of Journal)
Open Journal of Gastroenterology
Recommended Citation
Arisar, F. Q.,
Hamid, S.
(2018). Rapid Development of hepatocellular carcinoma after eradication of hepatitis C virus with directly acting antiviral treatment. Open Journal of Gastroenterology, 8(9), 295-305.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_med_gastroenterol/334
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.