Intensive versus routine blood pressure control in patients with type 2 diabetes: A meta-analysis and trial sequential analysis
Document Type
Article
Department
Medical College Pakistan
Abstract
Optimal blood pressure (BP) targets for type 2 diabetes remain controversial. Although intensive BP control reduces cardiovascular risk in the general population, its net benefit in diabetes is uncertain. We conducted a systematic review and meta-analysis of randomized controlled trials comparing intensive BP control (target < 130/80 mmHg or achieved systolic < 130 mmHg) with routine control in adults with type 2 diabetes. Databases (PubMed, Embase, Cochrane CENTRAL) were searched through November 2024; two reviewers independently extracted data and assessed bias. Random-effects meta-analysis estimated pooled relative risks (RRs) with 95% confidence intervals (CIs), and trial sequential analysis (TSA) assessed robustness. Eleven trials comprising 24,308 participants met inclusion criteria. Intensive BP control reduced stroke (RR: 0.64; 95% CI: 0.51-0.81) and major cardiovascular events (RR: 0.86; 95% CI: 0.72-1.03) with no significant differences in mortality or heart-failure hospitalization. TSA confirmed firm evidence for stroke reduction, mortality and heart failure results remained inconclusive.
AKU Student
yes
Publication (Name of Journal)
Journal of Hypertension
DOI
10.1097/HJH.0000000000004267
Recommended Citation
Ikram, J.,
Ali, A.,
Huma, S.,
Khan, M. M.,
Zaman, B.,
Khattak, A. I.,
Sawaira, F.,
Mushtaq, A.,
Zahid, A.,
Mankani, M. H.
(2026). Intensive versus routine blood pressure control in patients with type 2 diabetes: A meta-analysis and trial sequential analysis. Journal of Hypertension.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_mc/598
Comments
Volume, issue and pagination are not provided by author/publisher.