Outcomes of hematopoietic stem cell transplantation in primary plasma cell leukemia: A systematic review and meta-analysis
Document Type
Article
Department
AKU-Pakistan
Abstract
Background: Hematopoietic stem cell transplantation (HCT) is a pivotal treatment modality for primary plasma cell leukemia (pPCL). We aimed to examine the outcomes of allogeneic (allo) and autologous (auto) HCT in adult pPCL patients.
Methods: Following PRISMA guidelines, a comprehensive literature search was performed on PubMed, Cochrane, Embase, and Clinicaltrials.gov using relevant MeSH terms and keywords. Twelve original articles reporting outcomes of auto-HCT or allo-HCT in adult pPCL patients were included. The pooled analysis was performed using the 'meta' package in the R program (version 4.3.0).
Results: Our analysis included 1757 pPCL patients (1535 with auto-HCT, 222 with allo-HCT), and 49 % were males. The pooled 3 years overall survival (OS), progression-free survival/event-free survival (PFS/EFS), and relapse rate (RR) in auto-HCT were 51 % (95 % CI 0.4-0.61, I2=92 %, p = Conclusion: HCT remains pivotal in treating primary plasma cell leukemia. However, higher relapse rates warrant novel agents and clinical trials to improve transplant-related outcomes in this challenging subgroup.
Publication (Name of Journal)
Leukemia Research
DOI
10.1016/j.leukres.2024.107640
Recommended Citation
Shahzad, M.,
Iqbal, Q.,
Amin, M. K.,
Irfan, S.,
Warraich, S. Z.,
Dave, P.,
Basharat, A.,
Faisal, M. S.,
Jaglal, M.
(2025). Outcomes of hematopoietic stem cell transplantation in primary plasma cell leukemia: A systematic review and meta-analysis. Leukemia Research, 148.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_mc/506
Comments
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