Evaluating the effect of multivalvular disease on mortality after transcatheter aortic valve replacement for aortic stenosis: A meta-analysis and systematic review
Document Type
Review Article
Department
Medical College Pakistan
Abstract
Aims: To determine the prognosis of multivalvular disease in patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis.
Methods: Patients undergoing TAVR for aortic stenosis with covariate-adjusted risk of mortality associated with concomitant valve disease (mitral regurgitation [MR], mitral stenosis [MS] or tricuspid regurgitation [TR]) were included.
Results: Moderate-to-severe MR was associated with increased mortality at 30 days (hazard ratio [HR]: 1.60; 95% CI: 1.11-2.30; p = 0.01) and 1 year (HR: 1.87; 95% CI: 1.22-2.87; p = 0.004). The presence of all-grade MS did not impact 30-day or 1-year mortality (HR, 30 days: 1.60; 95% CI: 0.71-3.63; p = 0.26; and HR, 1 year: 1.90; 95% CI: 0.98-3.69; p = 0.06); however, an increased risk of 1-year mortality (HR: 1.67; 95% CI: 1.03-2.70; p = 0.04) was observed with severe MS compared with no MS. Moderate-to-severe TR had a higher risk of all-cause mortality at 1 year (HR: 1.49; 95% CI: 1.24-1.78; p < 0.001) compared with no or mild TR.
Conclusion: Moderate-to-severe MR or TR, and severe MS, significantly increase mid-term mortality after TAVR.
Publication (Name of Journal)
Future Cardiology
Recommended Citation
Siddiqi, T. J.,
Usman, M. S.,
Ahmed, J.,
Shahid, I.,
Ahmed, W.,
Alkhouli, M.
(2022). Evaluating the effect of multivalvular disease on mortality after transcatheter aortic valve replacement for aortic stenosis: A meta-analysis and systematic review. Future Cardiology.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_mc/278
Comments
Volume, issue, and pagination are not provided by the author/publisher.