Primary follicular dendritic cell sarcoma of breast: 2 further cases with review of the literature
Pathology and Laboratory Medicine
Follicular dendritic cell sarcoma (FDCS) is a tumor derived from antigen-presenting cells and can occur within lymphoid tissue or at extranodal sites. FDCS of the breast is remarkably rare, with only 4 cases previously reported in literature. FDCS appears grossly as a well-circumscribed, firm mass with a grey-yellow surface, areas of necrosis, and histologically comprises of spindled, oval, or epithelioid cells with intensely eosinophilic cytoplasm. Immunohistochemistry plays a key role in its diagnosis. Here we describe 2 cases of FDCS of breast in 2 women aged 70 and 35 years old, who presented with a palpable lump in the breast. One patient had concomitant invasive ductal carcinoma as well. We highlight the key histopathological and immunohistochemical features of the tumor.
International Journal of Surgical Pathology
Hanfee, A. R.,
Ghazi, K. R.,
Din, N. U.
(2021). Primary follicular dendritic cell sarcoma of breast: 2 further cases with review of the literature. International Journal of Surgical Pathology.
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