Primary follicular dendritic cell sarcoma of breast: 2 further cases with review of the literature

Authors

Amna Rashid Hanfee, Aga Khan UniversityFollow
Kinzah Razzak Ghazi, Aga Khan UniversityFollow
Zoonish Ashfaq, Aga Khan UniversityFollow
Naila Kayani, Aga Khan UniversityFollow
Nasir Ud Din, Aga Khan UniversityFollow

Document Type

Case Report

Department

Pathology and Laboratory Medicine

Abstract

Follicular dendritic cell sarcoma (FDCS) is a tumor derived from antigen-presenting cells and can occur within lymphoid tissue or at extranodal sites. FDCS of the breast is remarkably rare, with only 4 cases previously reported in literature. FDCS appears grossly as a well-circumscribed, firm mass with a grey-yellow surface, areas of necrosis, and histologically comprises of spindled, oval, or epithelioid cells with intensely eosinophilic cytoplasm. Immunohistochemistry plays a key role in its diagnosis. Here we describe 2 cases of FDCS of breast in 2 women aged 70 and 35 years old, who presented with a palpable lump in the breast. One patient had concomitant invasive ductal carcinoma as well. We highlight the key histopathological and immunohistochemical features of the tumor.

Comments

Volume, issue, and pagination are not provided by the author/publisher

Publication (Name of Journal)

International Journal of Surgical Pathology

Recommended Citation

Hanfee, A. R., Ghazi, K. R., Ashfaq, Z., Kayani, N., Din, N. U. (2021). Primary follicular dendritic cell sarcoma of breast: 2 further cases with review of the literature. International Journal of Surgical Pathology.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_mc/204