Generational changes in lung function in adults from several world regions: Results from the burden of obstructive lung disease study

Authors

• Jixuan Ma, University of Science and Technology, China
• Peter G J Burney, National Heart and Lung Institute,UK
• David M. Mannino, University of Kentucky,USA
• Christer Janson, Uppsala University, Sweden
• Thorarinn Gislason, Landspitali University Hospital, Iceland
• Daniel O. Obaseki, Landspitali University Hospital, Iceland
• Rain Jogi, Tartu University Hospital, Estonia
• Abdul Rashid, University College Dublin Malaysia
• Gregory E. Erhabor, Uppsala University, Sweden
• Asaad A. Nafees, Aga Khan UniversityFollow

Document Type

Article

Department

Community Health Sciences

Abstract

This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and the FEV1/FVC increased across successive birth cohorts in both high-income countries (HICs) and low- and middle-income countries (LMICs), with mean values rising steadily with later birth year. In fully adjusted models, FVC increased by 21.4 mL, FEV1 by 24.6 mL and FEV1/FVC by 0.25% per birth year. These positive associations were consistent across sex, smoking status and country-income subgroups (HICs and LMICs).

Comments

Volume, issue and pagination are not provided by author/publisher.

Publication (Name of Journal)

Thorax

DOI

10.1136/thorax-2026-225173

Recommended Citation

Ma, J., Burney, P. G., Mannino, D. M., Janson, C., Gislason, T., Obaseki, D. O., Jogi, R., Rashid, A., Erhabor, G. E., Nafees, A. (2026). Generational changes in lung function in adults from several world regions: Results from the burden of obstructive lung disease study. Thorax.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_chs_chs/1336