Docking prediction of amantadine in the receptor binding domain of spike protein of SARS-CoV-2

Authors

Abdul Mannan Baig, Aga Khan UniversityFollow
Areeba Khaleeq, Aga Khan UniversityFollow
Hira Syeda, Mohammad Ali Jinnah University, Karachi, Pakistan

Document Type

Article

Department

Biological and Biomedical Sciences

Abstract

Amantadine has recently been shown to improve patients with COVID-19. In addition to its known mechanism of actions, we performed docking prediction of this drug on the receptor-binding domain of severe acute respiratory syndrome coronavirus 2, SARS-CoV-2. We hypothesize that such interaction may possibly have contributed a role in the clinical improvements reported.

Publication (Name of Journal)

ACS Pharmacology & Translational Science

Recommended Citation

Baig, A. M., Khaleeq, A., Syeda, H. (2020). Docking prediction of amantadine in the receptor binding domain of spike protein of SARS-CoV-2. ACS Pharmacology & Translational Science, 3(6), 1430-1433.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_bbs/891