Does lipocalin-2 affect metabolic syndrome in hepatic infections?

Authors

Waqas Shahnawaz, Aga Khan UniversityFollow
Nawal Suhail, Aga Khan UniversityFollow
Muhammad Ahsan Iqbal Siddiqui, Aga Khan UniversityFollow
Saira Yasmeen, Jinnah Postgraduate Medical Centre, Karachi, PAK.
Syeda Sadia Fatima, Aga Khan UniversityFollow

Document Type

Article

Department

Biological and Biomedical Sciences

Abstract

Background and objective: Lipocalin-2 (LCN-2) is an adipokine that plays a protective role in various inflammatory disorders and regulates innate immune response to acute and chronic infections. However, scant information is available regarding the relationship between serum LCN-2 levels and type 2 diabetes mellitus (T2DM) occurring concurrently with chronic hepatic infections. The present study sought to investigate the association of LCN-2 with T2DM patients with hepatic infections.
Methods: The association of LCN-2 with T2DM, hepatic steatosis, and inflammation was tested in 37 non-T2DM noninfectious individuals (group A, control group) and 55 age-matched patients with T2DM and chronic infection (group B). Anthropometric data were measured and the body-fat percentage was calculated using bioelectrical impedance analysis (BIA). Hemoglobin (Hb), fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), liver function enzymes (LFEs), lipid profile, and total leukocyte count (TLC) were measured. Serum LCN-2 levels were measured using a commercially available sandwich enzyme-linked immunosorbent assay method.
Results: Levels of LCN-2 were significantly elevated in group B (1896.90 ± 73.13 ng/ml) versus control group A (263.58 ± 15.66 ng/mL; p<0.001). LCN-2 correlated moderately with alanine aminotransferase (ALT) (r=0.369), alkaline phosphatase ALP (r=0.419), and HbA1c (r=0.341) (p<0.01). All correlations were lost when adjusted for the presence of hepatitis, indicating that liver infection exacerbates insulin resistance.
Conclusion: Based on our findings, circulating LCN-2 is elevated in T2DM subjects with hepatitis B co-infection and may contribute towards deranged inflammatory response.

Comments

Pagination are not provided by the author/publisher

Publication (Name of Journal)

Cureus

Recommended Citation

Shahnawaz, W., Suhail, N., Siddiqui, M. I., Yasmeen, S., Fatima, S. S. (2020). Does lipocalin-2 affect metabolic syndrome in hepatic infections?. Cureus, 12(8), e10040.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_bbs/882

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.