The emergence of an unassigned complex recombinant form in a Pakistani HIV-infected individual

Authors

Uroosa Tariq, Aga Khan UniversityFollow
Ayesha Iftikhar, Shaukat Khanum Memorial Hospital and Research Centre, Lahore, Pakistan
Dilsha Zahid, Aga Khan UniversityFollow
Faisal Sultan, Shaukat Khanum Memorial Hospital and Research Centre, Lahore, Pakistan
Syed Faisal Mahmood, Agha Khan UniversityFollow
Sadaf Naeem Sadaf Naeem, University of Karachi, Karachi, Pakista
Syed Ali, Nazarbayev UniversityFollow
Syed Hani Abidi, Aga Khan University / University of OxfordFollow

Document Type

Report

Department

Biological and Biomedical Sciences; Medicine

Abstract

In Pakistan, the HIV situation has gone from an outbreak to a concentrated epidemic, and the virus has now crossed into the low-risk population. In addition, several new HIV outbreaks have occurred in different parts of the country. HIV-1 subtype A has been the major epidemic subtype in Pakistan; however, as the epidemic has grown, the emergence of several new subtypes and recombinant forms has been observed. Here, we present the first case and genetic analysis of an unassigned, complex recombinant form in a Pakistani HIV-infected individual with virological failure. Genetic analysis of the sequence indicated that this recombinant form is multi-drug resistant, harboring drug resistance mutations against more than one class of antiretroviral drugs.

Comments

Volume, issue, and pagination are not provided by the author/publisher

Publication (Name of Journal)

Archives of Virology

Recommended Citation

Tariq, U., Iftikhar, A., Zahid, D., Sultan, F., Mahmood, S., Sadaf Naeem, S., Ali, S., Abidi, S. H. (2020). The emergence of an unassigned complex recombinant form in a Pakistani HIV-infected individual. Archives of Virology.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_bbs/797