Title

Phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits 5-hydroxytryptamine-mediated potentiation of platelet aggregation induced by epinephrine

Document Type

Article

Department

Biological and Biomedical Sciences

Abstract

The role of phosphatidylinositol 3-kinase (PI 3-kinase) was investigated in human platelets exposed to varying doses of 5-hydroxytryptamine (5-HT) and subthreshold doses of epinephrine. The synergistic effect of 5-HT on epinephrine-induced aggregation was blocked by a specific inhibitor of PI 3-kinase, wortmannin, in a dose-dependent manner. However, there was no effect of inhibitors of protein kinase A (PKA) or protein kinase C (PKC). These studies suggest a role of PI 3-kinase in the 5-HT induced potentiation of epinephrine-mediated platelet aggregation.

Publication

Research Communications in Molecular Pathology and Pharmacology

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