Phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits 5-hydroxytryptamine-mediated potentiation of platelet aggregation induced by epinephrine
Document Type
Article
Department
Biological and Biomedical Sciences
Abstract
The role of phosphatidylinositol 3-kinase (PI 3-kinase) was investigated in human platelets exposed to varying doses of 5-hydroxytryptamine (5-HT) and subthreshold doses of epinephrine. The synergistic effect of 5-HT on epinephrine-induced aggregation was blocked by a specific inhibitor of PI 3-kinase, wortmannin, in a dose-dependent manner. However, there was no effect of inhibitors of protein kinase A (PKA) or protein kinase C (PKC). These studies suggest a role of PI 3-kinase in the 5-HT induced potentiation of epinephrine-mediated platelet aggregation.
Publication (Name of Journal)
Research Communications in Molecular Pathology and Pharmacology
Recommended Citation
Shah, B. H.,
Saeed, S. A.
(1995). Phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits 5-hydroxytryptamine-mediated potentiation of platelet aggregation induced by epinephrine. Research Communications in Molecular Pathology and Pharmacology, 89(2), 157-164.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_bbs/589