Evaluation of the liver protective potential of Cichorium intybus seed extract on Acetaminophen and CCl(4)-induced damage
Document Type
Article
Department
Biological and Biomedical Sciences
Abstract
The hepatoprotective activity of aqueous-methanolic extract of Cichorium intybus seeds was investigated against acetaminophen and CCl(4)-induced hepatic damage. Acetaminophen produced 100% mortality at the dose of 1 g/kg in mice while pretreatment of animals with plant extract (500mg/kg) reduced the death rate to 30%. Acetaminophen at the dose of 640 mg/kg produced liver damage in rats as manifested by the significant (P < 0.01) rise in serum levels of alkaline phosphatase (ALP), GOT and GPT to 393 ± 28, 767 ± 215 and 692 ± 191 IU/L (n = 10) respectively, compared to respective control values of 198 ± 15, 76 ± 07 and 39 ± 09. Pretreatment of rats with plant extract (500 mg/kg) significantly lowered (P < 0.01), the respective serum ALP, GOT and GPT levels to 228 ± 16, 68 ± 10 and 41 ± 08. Similarly, a hepatotoxic dose of CCl(4) (1.5 mL/kg; orally) significantly raised (P < 0.01), the serum ALP, GOT and GPT levels to 312 ± 20, 503 ± 98 and 407 ± 109 IU/L (n = 10) respectively, compared to respective control values of 215 ± 16, 79 ± 18 and 49 ± 10. The same dose of plant extract (500 mg/kg) was able to prevent significantly (P < 0.05) the CCl(4)-induced rise in serum enzymes and the estimated values of ALP, GOT and GPT were 222 ± 27, 114 ± 23 and 68 ± 14 respectively. Moreover, it prevented CCl(4)-induced prolongation in pentobarbital sleeping time confirming hepatoprotectivity and validates the folkloric uses of this plant in liver damage.
Publication (Name of Journal)
Phytomedicine
Recommended Citation
Gilani, A. H.,
Janbaz, K. H.
(1994). Evaluation of the liver protective potential of Cichorium intybus seed extract on Acetaminophen and CCl(4)-induced damage. Phytomedicine, 1(3), 193-197.
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https://ecommons.aku.edu/pakistan_fhs_mc_bbs/482