Document Type
Article
Department
Biological and Biomedical Sciences
Abstract
The study was tempted to explore the scientific basis for the medicinal use of Adiantum capillus-veneris L. in diarrhea using the in vivo and in vitro assays. The crude extract of dried leaves of A. capillus-veneris exhibited antidiarrheal effect against castor oil-induced diarrhea in mice at 300 and 500 mg/kg, similar to the effect loperamide. It was also found safe up to administered dose of 7 g/kg in mice. In isolated rabbit jejunum, extract of A. capillus-veneris showed a concentration-dependent relaxation of spontaneous and low K+ (25 mM)-induced contractions and had weak inhibitory effect on high K+ (80 mM), similar to the activity pattern of cromakalim, an ATP-dependent K+ channel opener. Interestingly, its inhibitory effect on spontaneous contractions was potentiated in the presence of atropine. These data demonstrates that A. capillus-veneris possesses antidiarrheal and antispasmodic properties mediated possibly through ATP-dependent K+ channels activation, thus providing scientific basis to its folk use in abdominal colic and diarrhea.
Publication (Name of Journal)
Bangladesh Journal of Pharmacology
Recommended Citation
Janbaz, K.,
Hassan, W.,
Mehmood, H.,
Gilani, A.
(2015). Antidiarrheal and antispasmodic activities of adiantum capillus-veneris are predominantly mediated through ATP-dependent K+ channels activation. Bangladesh Journal of Pharmacology, 10(1), 222-229.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_bbs/324