Emerging Insights for Better Delivery of Chemicals and Stem Cells to the Brain.
Document Type
Article
Department
Biological and Biomedical Sciences
Publication (Name of Journal)
ACS chemical neuroscience
Recommended Citation
Baig, A. M.
(2017). Emerging Insights for Better Delivery of Chemicals and Stem Cells to the Brain.. ACS chemical neuroscience, 8(6), 1119-1121.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_bbs/302
Comments
The human central nervous system and its vascularity has evolved a complex yet useful barricade, called the blood-brain barrier. The understanding of this barrier and the transport proteins that allow a selective access across it remains fundamental in designing chemicals and molecules that could cross it and prove therapeutically beneficial. After the recent findings of the brain-lymphatic link and the movement of chemical molecules from the central nervous system into general circulation, the model of the blood-brain barrier needs to be revisited. Here the author intends to discuss the components of the blood-brain barrier, debate the novel routes of administration and delivery systems for the drugs and embryonic stem cells that could cross or bypass the blood-brain barrier in order to reach the central nervous system.