Antispasmodic and Ca++ antagonist potential of marrubiin, a labdane type diterpene from Phlomis bracteosa

Authors

Javid Hussain, Kohat University of Science and Technology, Kohat, Pakistan
Riaz Ullah, Kohat University of Science and Technology, Kohat, Pakistan
Arif-ullah Khan, Aga Khan University
Fazal Mabood, College of Arts and Sciences University of Nizwa, Oman
Mohammad Raza Shah, University of Karachi, Karachi, Pakistan
Ahmed Al-Harrasi, College of Arts and Sciences University of Nizwa, Oman
Anwar Gilani, Aga Khan UniversityFollow

Document Type

Article

Department

Biological and Biomedical Sciences

Abstract

A tricyclic labdane type diterpene was isolated for the first time from ethyl acetate soluble part of Phlomis bracteosa. Its structure was confirmed by x-ray which was found to be marrubiin. When studied in isolated rabbit jejunum, marrubiin caused concentration-dependent relaxation of spontaneous and high K+ (80 mM)-induced contractions, like that caused by verapamil, indicating that marrubiin exhibits spasmolytic activity, possibly mediated through Ca++ channel blocking action.

Publication (Name of Journal)

Journal of Pharmacy Research

Recommended Citation

Hussain, J., Ullah, R., Khan, A., Mabood, F., Shah, M. R., Al-Harrasi, A., Gilani, A. (2011). Antispasmodic and Ca++ antagonist potential of marrubiin, a labdane type diterpene from Phlomis bracteosa. Journal of Pharmacy Research, 4(1), 178-180.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_bbs/227