Pharmacological studies on the antispasmodic, bronchodilator and anti-platelet activities of Abies webbiana.
Document Type
Article
Department
Biological and Biomedical Sciences
Abstract
This study evaluated the antispasmodic, bronchodilator and anti-platelet activities of Abies webbiana to rationalize some of its folk uses in gut and airways disorders and inflammation. The crude extract of A. webbiana (Aw.Cr) caused a complete relaxation of both spontaneous and K+ (80 mM)-induced contractions in isolated rabbit jejunum in a concentration-dependent manner. Aw.Cr shifted the Ca++ concentration–response curves (CRCs) to the right, in a fashion similar to verapamil, confirming its Ca++ channel blocking (CCB) effect. In isolated rabbit tracheal preparations, it caused relaxation of carbachol (1 μM) and K+ (80 mM)-induced contractions comparable to verapamil suggesting that the bronchodilatory effect may possibly be mediated through CCB activity. Aw.Cr was found to be the inhibitor of both ADP- and epinephrine-induced aggregation of human platelets thereby suggesting therapeutic potential in this plant against thrombo-embolic conditions. The exhibited anti-platelet effect was observed at low doses against epinephrine as compared to ADP. This study confirmed the presence of spasmolytic activity in Abies webbiana through possible blockade of Ca++ channels providing evidence for its folkloric use in gut and respiratory disorders in addition to anti-platelet activity.
Publication (Name of Journal)
Phytotherapy Research
Recommended Citation
Yasin, M.,
Janbaz, K. H.,
Imran, I.,
Gilani, A. H.,
Bashir, S.
(2014). Pharmacological studies on the antispasmodic, bronchodilator and anti-platelet activities of Abies webbiana.. Phytotherapy Research, 28(8), 1182-1187.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_bbs/193