Comparison of analgesic effect of tramadol alone and a combination of tramadol and paracetamol in day-care laparoscopic surgery
Document Type
Article
Department
Anaesthesia
Abstract
Background And Objective: To compare the analgesic efficacy of tramadol alone (1.5 mg kg(-1)) with a tramadol (1 mg kg(-1)) and paracetamol combination in day-care laparoscopic Patients. Methods: The analgesic efficacy of intravenous tramadol alone (1.5 mg kg(-1)) (group T) was compared with a combination of intravenous tramadol (1 mg kg(-1)) and oral paracetamol 1 g (group TP) in 60 day-care laparoscopic Patients in a prospective randomized double-blind clinical trial in a tertiary care hospital. Intraoperative haemodynamic responses and postoperative visual analogue scores were used to assess the analgesic efficacy. Results: Only one Patient (in group T) received a single dose of rescue analgesia intraoperatively. The highest pain scores were recorded at 30 min postoperatively in both groups, and rescue analgesia was needed in eight Patients in group T and in 13 Patients in group TP (P = 0.08). The incidence of moderate-to-severe nausea was high in group T (P = 0.001). Conclusion: We conclude that reducing the dose of tramadol to 1 mg kg(-1) and combining it with paracetamol 1 g orally decreased the incidence of side effects of tramadol without reducing analgesic efficacy.
Publication (Name of Journal)
European Journal of Anaesthesiology
Recommended Citation
Ali, M.,
Khan, F.
(2009). Comparison of analgesic effect of tramadol alone and a combination of tramadol and paracetamol in day-care laparoscopic surgery. European Journal of Anaesthesiology, 26(6), 475-479.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_anaesth/47