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COVID-19 had serious impacts on the lives and health of people across the globe. Due to the high-risk nature of their work midwives frequently report personal/professional adverse psychological impacts. However, there is a lack of studies examining the psychological impacts of the COVID-19 pandemic on private practice midwives in Indonesia and beyond. This study examines the psychological impacts of the pandemic on private practice midwives in Indonesia, as well as its association with individual adaptability and perceived knowledge about COVID-19. A total of 423 private practice midwives, who were active practitioners during the pandemic, completed an online survey, comprising five scales, including the Perceived Knowledge Scale, Individual Adaptability Measure, Depression Anxiety and Stress Scale-21, COVID-19 Anxiety Scale, and Financial Anxiety Scale. Although most respondents reported good psychological status, some still experienced mental health problems ranging from mild to severe levels. The mental health conditions of midwives were found to be significantly correlated with their perceived knowledge regarding COVID-19 and individual adaptability. The findings of this study highlight the need for psychological support for midwives to help them better adapt to this pandemic situation, particularly while working through the various phases of a pandemic with particularly vulnerable groups.