Date of Award

2-7-2022

Degree Type

Thesis

Degree Name

PhD in Nursing

First Advisor

Dr. Laila Akbar Ladak

Second Advisor

Dr. Khadija Nuzhat Humayun

Third Advisor

Ms. Sharifa Lalani

Department

School of Nursing and Midwifery, Pakistan

Abstract

Background: Type-I diabetes mellitus (TIDM) is a chronic metabolic disorder which require long-term management for good glycemic and metabolic control. Studies from high income countries (HICs) have reported that TIDM affects the health-related quality of life (HRQoL) in these children and adolescents. However, there is a lack of evidence from low- and middle-income countries (LMICs) such as Pakistan where the sociodemographic and the available resources are very different compared to HICs. Hence, it is important to explore the HRQoL of children and adolescents with TIDM, to address the needs of this patient population.
/="/">Purpose: This research study aimed to assess the HRQoL of children and adolescents (2-18 years) with TIDM, at a tertiary care hospital in Karachi, Pakistan.
/="/">Methodology: A quantitative cross-sectional analytical study design was utilized for this research study to assess the HRQoL of children and adolescents with TIDM from the patients’ perspective and their parents’ / primary care givers’ perspective as a proxy (for patients of 2-4 years), by utilizing the Pediatric Quality of Life Inventory™ (PedsQL™) generic-specific, Generic Core Scale (GCS) Version 4.0, and the disease-specific, Diabetes Module Version 3.2 (English and Urdu). Multivariate linear regression analysis was carried out to explore the factors associated with HRQoL among the children and adolescents with TIDM.
/="/">Results: The overall generic-specific HRQoL was found to be poor in all the domains of the GCS module. In multiple linear regression analysis, no associations were found between the predictors and the physical health summary score, psychosocial health summary score, and the GCS total health summary score. The overall diabetes-specific HRQoL was also found to be poor in all the domains of the diabetes module. In multiple linear regression analysis, the higher number of blood glucose monitoring were found to be statistically significantly associated with the diabetes symptoms summary score; increase in the age, and female gender, were found to be statistically significantly associated with the diabetes management summary score and diabetes total summary score.
/="/">Conclusion: The ongoing assessment and evaluation of HRQoL of children and adolescents with TIDM is an important indicator for determining disease prognosis, detection of problems, and identification of complications that might affect HRQoL. Hence, these should be included in diabetes management protocols. The integrated educational program and awareness are important at home, school, hospital settings, and at the community level for providing support to the children and adolescents with TIDM, to improve their HRQoL.

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1

Last Page

89

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