Participant recruitment, baseline characteristics and burden of cardiometabolic risk markers among adults with prediabetes in Kenya: insights from the fermented foods and prediabetes study

Authors

• Rosebella Iseme, Aga Khan UniversityFollow
• Alex Muia, Aga Khan University
• Jacob Shabani, Aga Khan UniversityFollow
• Samuel Mucheru, Aga Khan UniversityFollow
• Catherine Gathu, Aga Khan UniversityFollow
• Eliphas Gitonga, Kenyatta University, Kenya
• Redempta Mutisya, Kenyatta University, Kenya
• Peter Kioko, Aga Khan UniversityFollow
• Jalal Safipour, Linnaeus University, Sweden
• Cornelia Witthöft, Linnaeus University, Sweden

Document Type

Article

Department

Population Health (East Africa); Family Medicine (East Africa)

Abstract

Aims

Cardiometabolic abnormalities such as obesity, hypertension, and dyslipidemia are rising globally and straining health systems. This study assessed the burden of cardiometabolic risk factors among prediabetic adults in Kenya.

Methods

We analyzed baseline data from the Fermented Foods and Prediabetes Randomized Controlled Trial, which recruited adults with prediabetes (HbA1c 39–46 mmol/mol; 5.7%–6.4%) from Aga Khan University Hospital outreach clinics in five Kenyan counties. Standardized questionnaires and clinical assessments were conducted, with HbA1c measured via turbidimetric inhibition immunoassay. Data were managed in REDCap and analyzed in Stata v13. Poisson regression identified factors associated with co-occurrence of cardiometabolic risk factors.

Results

Of 210 participants (mean age 44.1 years; 60.5% female), 96.2% had at least one additional metabolic abnormality alongside prediabetes, including 16.7% with normal BMI. Excess weight was present in 83.3% and elevated blood pressure in 77.1%. In adjusted analyses, age was independently associated with a higher number of cardiometabolic risk factors (IRR = 1.013; 95% CI: 1.005–1.021; p = 0.002).

Conclusion

Prediabetic adults in Kenya exhibit a high clustering of cardiometabolic abnormalities, highlighting elevated risk of type 2 diabetes, cardiovascular disease, and premature mortality. Comprehensive interventions should target glucose, weight, blood pressure, lipids, and lifestyle factors.

Publication (Name of Journal)

Diabetes Research and Clinical Practice

DOI

https://doi.org/10.1016/j.diabres.2026.113214

Recommended Citation

Iseme, R., Muia, A., Shabani, J., Mucheru, S., Gathu, C., Gitonga, E., Mutisya, R., Kioko, P., Safipour, J., Witthöft, C. (2026). Participant recruitment, baseline characteristics and burden of cardiometabolic risk markers among adults with prediabetes in Kenya: insights from the fermented foods and prediabetes study. Diabetes Research and Clinical Practice, 235, 1-7.
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_popul_health/208

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.