Candida auris: a systematic review of a globally emerging fungal Pathogen in Africa
Document Type
Article
Department
Pathology (East Africa)
Abstract
Candida auris is a World Health Organization critical priority fungal pathogen. We conducted a systematic review to describe its epidemiology in Africa. PubMed and Google scholar databases were searched between January 2009 and September 2023 for clinical studies on C. auris cases and/or isolates from Africa. Reviews were excluded. We included 19 studies, involving at least 2529 cases from 6 African countries with the most, 2372 (93.8%), reported from South Africa. Whole-genome sequencing of 127 isolates identified 100 (78.7%) as clade III. Among 527 isolates, 481 (91.3%) were resistant to fluconazole, 108 (20.5%) to amphotericin B, and 9 (1.7%) to micafungin. Ninety of 211 (42.7%) patients with clinical outcomes died. C. auris is associated with high mortality and antifungal resistance, yet this critical pathogen remains underreported in Africa. Collaborative surveillance, fungal diagnostics, antifungals, and sustainable infection control practices are urgently needed for containment.
Publication (Name of Journal)
Open Forum Infectious Diseases
DOI
https://doi.org/10.1093/ofid/ofad681
Recommended Citation
Osaigbovo, I.,
Ekeng, B.,
Davies, A.,
Ebeigbe, E.,
Bongomin, F.,
Kanyua, A.,
Revathi, G.,
Oladele, R.
(2024). Candida auris: a systematic review of a globally emerging fungal Pathogen in Africa. Open Forum Infectious Diseases, 11(6), 1-9.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_pathol/291
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.