Document Type
Article
Department
Pathology (East Africa)
Abstract
Recent advances in thefield of immuno-oncology have brought transformative changes in the management ofcancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis andtreatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged aspotent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, therebyexpanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing thephenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinicallyrelevant biomarkers with high-throughput multiplex immunophenotyping of tumour samples has great potential toguide appropriate treatment choices. Moreover, the emergence of novel multi-marker imaging approaches can nowprovide unprecedented insights into the tumour microenvironment, including the potential interplay betweenvarious cell types. However, there are significant challenges to widespread integration of these technologies in dailyresearch and clinical practice. This review addresses the challenges and potential solutions within a structuredframework of action from a regulatory and clinical trial perspective. New developments within thefield ofimmunophenotyping using multiplexed tissue imaging platforms and associated digital pathology are also described,with a specific focus on translational implications across different subtypes of cancer.
Publication (Name of Journal)
The Journal of Pathology
DOI
https://doi.org/10.1002/path.6238
Recommended Citation
Sayed, S.,
Jahangir, C. A.,
Page, D.,
Broeckx, G.,
Gonzalez, C.,
Burke, C.,
Murphy, C.,
Reis-Filho, J.,
Ly, A.,
Harms, P.
(2024). Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer.. The Journal of Pathology, 262(3), 255-389.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_pathol/279
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.