Dysregulation of circulating angiopoietins is associated with low birth weight in children who are HIV-exposed and uninfected

Authors

• Julia Sawatzky, University of Alberta, Canada
• Andrea Conroy, Indiana University School of Medicine, USA
• Jeanne Brochon, Université de Montréal, Canda
• Fatima Kakkar, Université de Montréal, Canda
• Jason Brophy, Children's Hospital of Eastern Ontario, Canada
• Sophie Namasopo,, Kabale District Hospital, Uganda
• Robert Opoka, Aga Khan UniversityFollow
• Michael Hawkes, University of Alberta, Canada

Document Type

Article

Department

Paediatrics and Child Health (East Africa)

Abstract

HIV exposure in utero is associated with low birth weight (LBW), even in the absence of vertical transmission. To explore mechanism, we evaluated endothelial markers angiopoietin (Ang)-1 and Ang-2 among 294 uninfected Ugandan infants born to women with HIV (WWH). The median Ang-2/Ang-1 ratio was 0.051 [interquartile range (IQR) 0.023–0.19] among infants with LBW and 0.018 (IQR 0.010–0.037) among controls (P = 0.00011). Endothelial dysregulation may contribute to LBW among infants born to WWH.

Publication (Name of Journal)

AIDS

DOI

10.1097/QAD.0000000000004424

Recommended Citation

Sawatzky, J., Conroy, A., Brochon, J., Kakkar, F., Brophy, J., Namasopo,, S., Opoka, R., Hawkes, M. (2026). Dysregulation of circulating angiopoietins is associated with low birth weight in children who are HIV-exposed and uninfected. AIDS, 40(5), 696-699.
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/619