Chitinase-3-like 1 is associated with stunting and developmental delay in HIV-exposed but uninfected Ugandan children

Authors

Elspeth MacBain, University of British Columbia, Canada
Andrea L. Conroy, Indiana University School of Medicine, USA
Jason Brophy, Children's Hospital of Eastern Ontario, Ottawa
Fatima Kakkar, Centre Hospitalier Universitaire Sainte-Justine, Canada
Sophie Namasopo, Kabale District Hospital, Uganda
Robert Opoka, Aga Khan UniversityFollow
Michael T. Hawkes, University of British Columbia, Canada

Document Type

Article

Department

Paediatrics and Child Health (East Africa)

Abstract

Chronic systemic inflammation may affect linear growth and neurodevelopment in children who are HIV-exposed but uninfected (cHEU). We examined plasma concentrations of neutrophil activation marker chitinase-3-like protein 1 (CHI3L1) levels in 153 Ugandan cHEU. At 18 months of age, CHI3L1 levels were inversely correlated with height-for-age z scores (τB = −0.17, P = 0.0035) and a normalized developmental score (τB = −0.20, P = 0.00027). CHI3L1 appears to be a marker of adverse growth and development in cHEU.

AKU Student

no

Publication (Name of Journal)

AIDS

DOI

https://doi.org/10.1097/QAD.0000000000004389

Recommended Citation

MacBain, E., Conroy, A. L., Brophy, J., Kakkar, F., Namasopo, S., Opoka, R., Hawkes, M. T. (2026). Chitinase-3-like 1 is associated with stunting and developmental delay in HIV-exposed but uninfected Ugandan children. AIDS, 40(2), 263-266.
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/610