Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria.
Document Type
Article
Department
Paediatrics and Child Health (East Africa)
Abstract
Systemic tumour necrosis factor-α (TNF-α) may contribute to the pathogenesis of cerebral malaria (CM) by promoting endothelial activation and parasite sequestration. However, less is known about the role of central nervous system (CNS) TNF-α in CM. We assessed plasma (n=249) and cerebrospinal fluid (CSF) (n=167) TNF-α levels in Ugandan children with CM, plasma TNF-α in Ugandan community control children (n=198) and CSF TNF-α in North American control children who had recovered from leukaemia (n=13). Plasma and CSF TNF-α were measured by magnetic bead assay. We compared plasma and CSF TNF-α levels in children with CM to mortality, acute and chronic neurologic deficits and long-term neurocognitive impairment. Plasma and CSF TNF-α levels were higher in CM than control children.
Publication (Name of Journal)
Parasite Immunology
DOI
https://doi.org/10.1111/pim.12438
Recommended Citation
Estela, S.,
Benson, O.,
Idro, R.,
Bangirana, P.,
Opoka, R.,
Gregory, P.,
Conroy, A.,
John, C.
(2017). Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria.. Parasite Immunology, 39(7), 1-9.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/508
Comments
This work was published before the author joined Aga Khan University.