Cutting edge: merocytic dendritic cells break T cell tolerance to beta cell antigens in nonobese diabetic mouse diabetes.
Document Type
Article
Department
Paediatrics and Child Health (East Africa)
Abstract
In type 1 diabetes, the breach of central and peripheral tolerance results in autoreactive T cells that destroy insulin-producing, pancreatic β cells. In this study, we identify a critical subpopulation of dendritic cells responsible for mediating both the cross-presentation of islet Ags to CD8+ T cells and the direct presentation of β cell Ags to CD4+ T cells. These cells, termed merocytic dendritic cells (mcDCs), are more numerous in the NOD mouse and, when Ag-loaded, rescue CD8+ T cells from peripheral anergy and deletion while stimulating islet-reactive CD4+ T cells. When purified from the pancreatic lymph nodes of overtly diabetic NOD mice, mcDCs break peripheral T cell tolerance to β cells in vivo and induce rapid onset type 1 diabetes in the young NOD mouse. Thus, the mcDC subset appears to represent the long-sought APC responsible for breaking peripheral tolerance to β cell Ags in vivo.
Publication (Name of Journal)
The Journal of Immunology
DOI
https://doi.org/10.4049/jimmunol.1001398
Recommended Citation
Katz, J. D.,
Ondr, J. K.,
Opoka, R.,
Garcia, Z.,
Janssen, E. M.
(2010). Cutting edge: merocytic dendritic cells break T cell tolerance to beta cell antigens in nonobese diabetic mouse diabetes.. The Journal of Immunology, 185(4), 1999-2003.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/406
Comments
This work was published before the author joined Aga Khan University.