Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways
Document Type
Article
Department
Paediatrics and Child Health (East Africa)
Abstract
Cerebral malaria (CM), coma caused by Plasmodium falciparum-infected red blood cells (iRBCs), is the deadliest complication of malaria. The mechanisms that lead to CM development are incompletely understood. Here we report on the identification of activation and inhibition pathways leading to mouse CM with supporting evidence from the analysis of human specimens. We find that CM suppression can be induced by vascular injury when sporozoites exit the circulation to infect the liver and that CM suppression is mediated by the release of soluble factors into the circulation. Among these factors is insulin like growth factor 1 (IGF1), administration of which inhibits CM development in mice.
Publication (Name of Journal)
American Society for Microbiology
Recommended Citation
Cha, S.,
Yu, X.,
Gregory, B.,
Lee, Y. S.,
Ishino, T.,
Opoka, R.,
John, C.,
Loreno, M. J.
(2022). Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways. American Society for Microbiology, 13(1).
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/288
Comments
This work was published before the author joined Aga Khan University.