Immune and endothelial activation markers and risk stratification of childhood pneumonia in Uganda: A secondary analysis of a prospective cohort study

Authors

Chloe McDonald, University Health Network, Canada
Aleksandra Leligdowicz, University of Western Ontario, Canada
Andrea Conroy, Indiana University, United States of America
Andrea Weckman, University Health Network, Canada
Melissa Richard-Greenblatt, University of Toronto,Canada
Michelle Ngai, University Health Network, Canada
Clara Erice, University Health Network, Canada
Kathleen Zhong, University Health Network, Canada
Sophie Namasopo, Kabale Regional Referral Hospital, Uganda
Robert Opoka, Aga Khan UniversityFollow

Document Type

Article

Department

Graduate School of Media and Communications

Abstract

Despite the global burden of pneumonia, reliable triage tools to identify children in low-resource settings at risk of severe and fatal respiratory tract infection are lacking. This study assessed the ability of circulating host markers of immune and endothelial activation quantified at presentation, relative to currently used clinical measures of disease severity, to identify children with pneumonia who are at risk of death.

Comments

This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

PLoS Medicine

Recommended Citation

McDonald, C., Leligdowicz, A., Conroy, A., Weckman, A., Richard-Greenblatt, M., Ngai, M., Erice, C., Zhong, K., Namasopo, S., Opoka, R. (2022). Immune and endothelial activation markers and risk stratification of childhood pneumonia in Uganda: A secondary analysis of a prospective cohort study. PLoS Medicine, 19(7).
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/259