Circulating markers of neutrophil activation and lung injury in pediatric pneumonia in low-resource settings
Document Type
Article
Department
Paediatrics and Child Health (East Africa)
Abstract
Diagnostic biomarkers for childhood pneumonia could guide management and improve antibiotic stewardship in low-resource settings where chest x-ray (CXR) is not always available. In this cross-sectional study, we measured chitinase 3-like protein 1 (CHI3L1), surfactant protein D (SP-D), lipocalin-2 (LCN2), and tissue inhibitor of metalloproteinases-1 (TIMP-1) in Ugandan children under the age of five hospitalized with acute lower respiratory tract infection. We determined the association between biomarker levels and primary end-point pneumonia, indicated by CXR consolidation. We included 89 children (median age 11 months, 39% female). Primary endpoint pneumonia was present in 22 (25%). Clinical signs were similar in children with and without CXR consolidation. Broad-spectrum antibiotics (ceftriaxone) were administered in 83 (93%). Levels of CHI3L1, SP-D, LCN2 and TIMP-1 were higher in patients with primary end-point pneumonia compared to patients with normal CXR or other infiltrates. All markers were moderately accurate predictors of primary end-point pneumonia, with area under receiver operator characteristic curves of 0.66-0.70 (p
Publication (Name of Journal)
Pathogens and Global Health
Recommended Citation
Konrad, E. R.,
Soo, J.,
Conroy, A.,
Namasopo, S.,
Opoka, R.,
Hawkes, M.
(2022). Circulating markers of neutrophil activation and lung injury in pediatric pneumonia in low-resource settings. Pathogens and Global Health, 1-9.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/239
Comments
This work was published before the author joined Aga Khan University.