Exposure to HIV-1 during delivery and mother-to-child transmission.
Obstetrics and Gynaecology (East Africa)
The correlation between the presence of HIV-1 in maternal cervico-vaginal secretions and in the infant's oro-pharyngal secretions at birth, and mother-to-child HIV transmission (MTCT) were examined to obtain a better understanding of its mechanism.
Women without medical and obstetrical complications, living within a reasonable distance of the government hospital in Mombasa, Kenya, were recruited after informed consent. Maternal and infant characteristics were collected. Polymerase chain reaction was used to detect HIV-1 in cervico-vaginal and oro-pharyngal secretions. Infants were tested for HIV-1 by polymerase chain reaction within 48 h and at 6 weeks after delivery.
Between April 1998 and April 1999, 228 woman–infant pairs were included in the study. HIV-1 DNA in cervico-vaginal secretions was independently associated with HIV-1 maternal viral load and with infant birth-weight, whereas HIV-1 RNA was associated with maternal viral load and maternal age. HIV-1 DNA in the oro-pharyngal secretions was also independently associated with maternal viral load. MTCT rate at the age of 6 weeks was 23.6%. Intrapartum and early postpartum HIV transmission was independently associated with maternal viral load [adjusted odds ratio (OR), 1.6; 95% confidence interval (CI),1.0–2.7], detection of HIV-1 RNA in cervico-vaginal secretions (adjusted OR, 3.2; 95% CI, 1.5–7.3) and of HIV-1 DNA in oro-pharyngal secretions (adjusted OR, 3.2; 95% CI, 1.1–9.0).
As far as is known, this is the first study showing that infant exposure to HIV-1 in the birth canal and the presence of HIV-infected cells in the infant's oro-pharyngal cavity are independently associated with intrapartum and early postpartum MTCT. It supports the hypothesis that MTCT could occur through the oral route.
(2000). Exposure to HIV-1 during delivery and mother-to-child transmission.. AIDS, 14(15), 2341-2348.
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_obstet_gynaecol/444